The consumption and sale of alcohol is banned in the North African country, even though it is available on the black market.
In a statement on its website, the ministry said 38 people had died in Tripoli and another 13 had died while on their way to Tunisia for treatment.
"There have been 378 cases of alcohol poisoning so far," the ministry said, adding the illegal concoction was believed to have contained methanol. The deaths were among that figure.
It gave no further details about the alcohol or its source.
With its long, porous borders, Libya has seen a significant increase in drug and alcohol trafficking since the 2011 war that ousted dictator Moammar Gadhafi.